Forslean (forskolin) and Increased cAMP Levels

Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP belongs to a class of substances known as "second messengers" and is one of the most important cell-regulating compounds. Among its many roles, cAMP activates numerous other enzymes involved in diverse cellular functions. Hormones and neurotransmitters also activate adenylate cyclase, but Forskolin appears to be able to activate adenylate cyclase by itself. Thus, Forskolin can increase cyclic AMP without the assistance of hormones or neurotransmitters.